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Interactive GIN-McMaster Guideline Development Checklist in GRADEpro - 04 January 2019

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GIN-McMaster Guideline Development Checklist is a comprehensive list of topics and items outlining the practical steps to consider for developing guidelines. The Guideline Development Checklist project is a partnership between the Guidelines International Network (GIN) and McMaster University. The checklist is intended for use by guideline developers to plan and track the process of guideline development and to help ensure that no key steps are missed.

Newest GRADEpro version brings the tool in the form of interactive list integrated to the TASKS module.

Each step of the list offers plenty of information about the guideline development process, including tools supporting the process, related references and learning materials.

You can also use the tool to follow along the process by checking each step completed by his team and adding important comments.

We hope that inclusion of this great learning material will additionally strengthen our users understanding of different aspects of guideline development process

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ROBINS-I assessment integration - 21 December 2018

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ROBINS-I (Risk Of Bias In Non-randomized Studies – of Interventions) is a tool used to assess a risk of bias in non-randomized studies of interventions.



Outcomes in GRADEpro based on observational studies have now possibility to enable ROBINS-I assessment by clicking the checkbox, as presented on the illustration above. This will change the certainty of evidence calculation in evidence table and options available in risk of bias assessment to the one used in ROBINS-I method.

GRADE method calculates certainty of evidence in observational studies, starting from LOW (Which represents lack of certainty in non-randomized studies) certainty and lowering to VERY LOW with any other serious and very serious risk of bias/inconsistency/indirectness/imprecision or publication bias assessment.

ROBINS-I option modifies this method. Certainty of evidence of non-randomized studies starts from HIGH and is lowered by 1 level (HIGH/MODERATE/LOW/VERY LOW) each time risk of bias assessment is lowered.

Example: Outcome based on non-randomized studies with “very serious” risk of bias and “serious inconsistency” will be assessed as “VERY LOW” certainty of evidence.


Starting from HIGH

Lowered 2 levels to LOW for “very serious” Risk of Bias

Lowered 1 level to VERY LOW for “serious” inconsistency of data


You can learn more about ROBINS-I Tool here:


I have a problem with this functionality. Where can I ask for help?

Please send us a support ticket by using the “feedback” function in GRADEpro, or write us directly at