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Let’s meet at Global Evidence Summit! - 05 September 2017

POSTED BY POSTED IN Company News | No Comments

The Evidence Prime team is very excited to be attending the Global Evidence Summit in Cape Town. The synergy of effort from the annual Cochrane Collaboration Colloquium and the G-I-N conference will certainly provide some interesting meeting opportunities. Zbyszek and Eric will be happy to meet all those who would like to know more about our solutions. If you do not see those gentlemen in the crowd, please write to, or tweet out to @evidence_prime and we will certainly arrange a meeting.
We are already familiar with the excellent program of the conference. Out of the labyrinth of lectures, discussions, workshops and presentations we provide here a list of GRADE events. The most experienced GRADE experts will explain the basics, and also point out some new directions and new applications to which the GRADE methodology may be applied. There will be very hands-on activities on specific issues, which will facilitate and improve the quality of your work in systematic reviews and guideline development. Those who are still undecided about which events to attend in Cape Town should definitely look into one of these meetings:

Monday, 11 September 2017

9:00 to 16:00
Developing GRADE guidance for overviews of systematic reviews

Wednesday, 13 September 2017

11:00 to 12:30
Integrating GRADE network meta-analysis SoF tables in network meta-analysis reports

14:00 to 15:30
Assessing confidence in qualitative evidence used in guidelines: Benefits and challenges when applying GRADE-CERQual

16:00 to 17:30
Uptake and Implementation of GRADE among guideline developers in the United States

Thursday, 14 September 2017

11:00 to 12:30
Presentation of time-to-event outcomes in GRADE Summary of Finding (SOF) tables: Evaluation of Cochrane Cancer Reviews

Confidence in qualitative synthesized findings: A principled and pragmatic critique of ConQual and GRADE-CERQual

Applying the GRADE-CERQual approach: Experiences from the development of an EPOC qualitative-evidence synthesis

14:00 to 15:30
The GRADE-CERQual approach for assessing how much confidence to place in findings from qualitative evidence syntheses

Friday, 15 September 2017

11:00 to 12:30
Making the GRADE approach for network meta-analysis more efficient

Saturday, 16 September 2017

11.00 to 12.30
GRADE approach for determining certainty of evidence on how patients value outcomes

Creating evidence tables for use in systematic reviews and guideline development: GRADE approach

Systematic reviews of prognostic studies V: Using GRADE to appraise bodies of evidence about overall prognosis and prognostic factors

14:00 to 15:30
Using GRADE to integrate randomized and non-randomized studies in systematic reviews

Using GRADE in public-health guidelines – challenges and some solutions?

Assessing the certainty of the evidence from network-meta analysis using the GRADE approach

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Are any alternatives for evidence based medicine? - 27 June 2017

POSTED BY POSTED IN General analyses | No Comments

GRADEpro is the software of choice for experts who care about the highest quality of evidence and the most reliable sources in medical science. Of course a lot of ‘scientists’ still prefer some alternative approaches. As summer vacation begins for many of us, let us recall the clever recap Seven alternatives to evidence based medicine” by David Isaacs and Dominic Fitzgerald in BMJ. This witty article was written almost decade ago, but we find its relevance very much alive today:

(1) Eminence based medicine – when doctors have a touching faith in clinical experience, which has been defined as “making the same mistakes with increasing confidence over an impressive number of years.”

 (2) Vehemence based medicine – The substitution of volume for evidence is an effective technique for brow beating your more timorous colleagues and for convincing relatives of your ability.

(3) Eloquence based medicine – Sartorial elegance and verbal eloquence are powerful substitutes for evidence.

(4) Providence based medicine – If the caring practitioner has no idea of what to do next, the decision may be best left in the hands of the Almighty.

(5) Diffidence based medicine – Some doctors see a problem and look for an answer. Others merely see a problem. The diffident doctor may do nothing from a sense of despair.

(6) Nervousness based medicine – Fear of litigation is a powerful stimulus to overinvestigation and overtreatment.

(7) Confidence based medicine – restricted to surgeons. In the table there are more details: marker – bravado, measuring device – sweat test, unit of measurement – no sweat.

This bright classification was supplemented by Aldo Mariotto with the term:

(8) Propaganda based medicine, that is connected with pharmaceutical representatives’ influence on physicians.

… we can’t find any culminating point, just use GRADEing!

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The new beginning - 08 June 2017

POSTED BY POSTED IN GRADE methodology | No Comments

Welcome to the new Evidence Prime website. As so far, information on the GRADEpro releases will be posted on our blog. We will try to familiarize you also with events related to GRADE Working Group and publication of articles on GRADE methodology.

We recommend the article “GRADE Evidence to Decision (EtD) frameworks for adoption, adaptation, and de novo development of trustworthy recommendations: GRADE-ADOLOPMENT” published in the Journal of Clinical Epidemiology (January 2017, v. 81, pages 101-110). Professor Schünemann and his collaborators present a new approach to guideline production that the authors call GRADE-ADOLOPMENT. It combines the advantages of adoption, adaptation, and de novo development of guidelines. GRADE EtDs are a core component of the approach, as they transparently present setting-specific evidence. The approach facilitates structured interaction and deliberation with panel members during guideline panel meetings and can save important resources.

It is worth noting that GRADEpro has in recent months developed new tools of interaction within expert panel and decision-making within the guideline development team. PanelVoice and Panellist allow remote team members to contact, limit the need for personal meetings, and make sure they are quick to speed up the process and reduce meeting time (if meeting is needed).

We are always happy to hear your feedback on GRADEpro’s application and feature offerings.